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Drugs Information Healthline

Methylprednisolone Oral Tablet: Risks and Side Effects

Highlights for Methylprednisolone

  1. Methylprednisolone oral tablet is available as both a generic and brand-name drug. Brand name: Medrol.
  2. This drug also comes as an injectable suspension and injectable solution. These forms are only given by a healthcare provider.
  3. Methylprednisolone is used to reduce inflammation in many conditions. These include endocrine diseases, severe allergies, ulcerative colitis, and multiple sclerosis. It’s also used to treat rheumatic diseases, such as rheumatoid arthritis and osteoarthritis.
What is Methylprednisolone?

Methylprednisolone oral tablet is a prescription drug that’s available as the brand-name drug Medrol. It’s also available as a generic drug.

Generic drugs usually cost less than the brand-name version. In some cases, the brand-name drug and the generic version may be available in different forms and strengths.

Methylprednisolone also comes as a suspension or solution. Those forms are given to you by a healthcare provider.

Why it’s used

This drug is used to treat many conditions. It helps to control inflammation and to modify your body’s immune response. The conditions it’s used to treat include:

  • endocrine disorders such as primary or secondary adrenocortical insufficiency
  • rheumatic disorders such as rheumatoid arthritis or psoriatic arthritis
  • collagen diseases such as lupus or systemic dermatomyositis
  • skin diseases such as psoriasis or Stevens-Johnson syndrome
  • severe allergies that haven’t been controlled with other treatment, such as seasonal or year-round allergies or allergic reactions to medications
  • eye problems such as swelling or ulcers (sores) in your eye
  • stomach or intestinal problems such as ulcerative colitis or Crohn’s disease
  • respiratory problems such as lung damage caused by beryllium poisoning, or by Loeffler’s syndrome that’s not controlled by other treatments
  • blood disorders such as low levels of platelets in adults, or lack of red blood cells in children
  • neoplastic diseases such as blood cancer or cancer in the lymphatic system in adults
  • multiple sclerosis flare-ups
  • infections, such as trichinosis with brain or heart problems

How it works

Methylprednisolone belongs to a class of drugs called glucocorticoids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Methylprednisolone works by decreasing inflammation and changing your body’s immune response. This reduces the inflammation caused by your condition.

Methylprednisolone side effects

Methylprednisolone oral tablet doesn’t cause drowsiness, but it can cause other side effects.
More common side effects
The more common side effects of methylprednisolone can include:
  • headache
  • nausea and vomiting
  • weight gain
  • confusion, excitement, and restlessness
  • swelling of your ankles, feet, or hands
  • skin problems, such as acne, thin skin, and shiny skin
  • increased thirst
  • infection
  • high blood pressure
  • muscle weakness
  • depression
If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
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