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Cardio Health Healthline

Nuclear stress test: What does it involve?

A nuclear stress test uses a small amount of radioactive substance to determine the health of the heart and blood flow to the heart.
The test aims to find out whether any areas of the heart muscle are not receiving enough blood flow during exercise. It is similar to the exercise stress test or pharmacological, or chemical, stress test.
It is also known at the thallium stress test, a myocardial perfusion scan, or a radionuclide test.
The test can be done while the patient is resting or doing exercise. The radioactive substance that is injected into the patient is called a radionuclide.
The test takes about 3 to 4 hours.
Although the patient is exposed to a small amount of radiation, the test is considered safe.


The nuclear stress test can help to diagnose a heart condition by giving vital information.
This data includes:
  • the size of the heart chambers
  • how well the heart is pumping blood
  • whether there is any damage to the heart
  • if there is any blockage or narrowing of the coronary arteries that provide blood to the heart
  • the effectiveness of any current treatment.
The test can also help determine whether the patient is suitable for a cardiac rehabilitation program, and if so, how hard they should exercise.

Nuclear stress test with exercise

In the nuclear stress test with exercise, a radionuclide, such as thallium or technetium, is injected into a vein in the hand or arm.

When the radionuclide has circulated through the blood stream, a gamma camera takes pictures of the heart while the patient is lying down. This is known as the “rest scan” of the heart.

The patient then moves onto a treadmill. The treadmill starts slowly and gradually picks up speed and incline, to simulate walking or running uphill.

At peak exercise, more radionuclide is injected into the patient. When the radionuclide has passed through the blood stream, the gamma camera takes more pictures of the heart. This is known as the “stress scan” of the heart.

The radionuclide helps to identify blocked or partially blocked arteries on the scans, because blocked arteries do not absorb the radionuclide into the heart. They are known as “cold spots.”

Without exercise

Patients with severe arthritis may be unable to do the physical activity required in a test with exercise. These patients may do the chemical nuclear stress test
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